Pantethine 500mg
A Useful Supplement for Cholesterol Maintenance
Pantethine 500 mg, provided by Douglas Laboratories®, offers 500 mg Pantethine in tablet form. Pantethine is the biologically active form of Pantothenic acid (vitamin B5), a proven treatment in dyslipidemia (disorders of blood lipids, including high cholesterol).
Functions
Cholesterol is a blood lipid, a fatty substance that is found in all parts of the body. When the concentration of cholesterol in the blood is too high, many problems, including heart disease, can occur. While cholesterol is manufactured within the body,
the average “American diet” provides an excessive intake of cholesterol and fat, leading to many serious health problems. An effective supplement that has proven to help reduce low density lipoproteins (LDL – the “bad cholesterol”) while simultaneously raising high density lipoproteins (HDL—the “good” cholesterol) is pantethine. In study after study, this beneficial supplement has proven to help patients control their cholesterol levels.
A number of studies focused on a group of people with particular health concerns (i.e. diabetics, peri-menopausal, etc.) and in each conclusion, pantethine worked in these health conditions without any detrimental side effects. The metabolic activity of pantethine is probably due to its role in the synthesis of CoA and acyl carrier proteins. CoA is a cofactor in over 70 enzymatic pathways including fatty acid oxidation, carbohydrate metabolism, pyruvate degradation, amino acid catabolism, heme synthesis, acetylcholine synthesis, and phase II detoxification acetylation. ACP is an essential component of the fatty acid synthase complex required for fatty acid elongation. While the exact mechanism of action of pantethine in normalizing parameters associated with dyslipidemia is unknown, several explanations have been proposed. Some authors have suggested pantethine might be capable of directly modulating the action of several enzymes involved in cholesterol synthesis. The efficacy of pantethine in normalizing parameters of dyslipidemia might also be due to its ability to increase CoA levels. Theoretically, if pantethine enhances the formation of CoA, the additional CoA might then combine with free acetyl groups to form acetyl-CoA. The acetyl-CoA could then be directed into the TCA cycle or beta-oxidation at the expense of cholesterol formation.
In addition to its cholesterol lowering abilities, several human and animal studies have concluded that pantethine may support other functions, including the healthy metabolism of blood glucose, as well as adrenal and eye health.
Indications
Pantethine tablets may be a useful dietary supplement for individuals who wish to support their cardiovascular system and help maintain healthy cholesterol levels.
Formula
Each tablet supplies:
Pantethine ... 500 mg
Suggested Use
Adults take 1 tablet daily with meals or as directed by physician.
Side Effects
No adverse side effects reported.
References
Binaghi P, Cellina G, Lo Cicero G, et al. Evaluation of the cholesterol-lowering effectiveness of pantethine in women in perimenopausal age. Minerva Med 1990;81:475-479.
Coronel F, Tornero F, Torrente J, Naranjo P, De Oleo P, Macia M, Barrientos A. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11(1):32-6.
Donati C, Bertieri RS, Barbi G. Pantethine, diabetes mellitus and
atherosclerosis. Clinical study of 1045 patients. Clin Ter 1989 Mar
31;128(6):411-22.
Gensini GF, Prisco D, Rogasi PG, et al. Changes in fatty acid
composition of the single platelet phospholipids induced by pantethine treatment. Int J Clin Pharmacol Res 1985;5:309-318.
Hiramatsu K, Nozaki H, Arimori S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J Exp Clin Med 1981;6:49-57.
Murai A, Miyahara T, Tanaka T, et al. The effects of pantethine on lipid and lipoprotein abnormalities in survivors of cerebral infarction. Artery 985;12:234-243.
Nomura H, Kimura Y, Okamoto O, Shiraishi G. Effects of antihyperlipidemic drugs and diet plus exercise therapy in the treatment of patients with moderate hypercholesterolemia. Clin Ther 1996 May-Jun;18(3):477-82
Osono Y, Hirose N, Nakajima K, Hata Y. The effects of pantethine on fatty liver and fat distribution. J Atheroscler Thromb 2000;7(1):55-8.
Prisco D, Rogasi PG, Matucci M, et al. Effect of oral treatment with pantethine on platelet and plasma phospholipids in IIa hyperlipoproteinemia. Angiology 1987;38:241-247.
Disclaimer
These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.
We at Westlake labs take heavy metal contamination seriously and thus test our products routinely to assure quality. We offer a survey compared to big box store brands randomly obtained over the last year.